Position in Cancer

August 04, 2011

 Ubiquitin  Ligases:


A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses mechanisms of ubiquitination and the role of E3 ubiquitin ligases in biology and disease. This position is to carry out work as part of a multi-disciplinary collaborative team to (1) develop in vitro assays to identify inhibitors of E3 ligases from small molecule compound collections that we have generated; (2) subsequently validate the identified inhibitors all the way to therapeutic efficacy in animal models (cancer xenografts); and (3) utilize identified inhibitors as tools to study the biology of the target E3 and to elucidate molecular mechanisms of ubiquitination.

Selected references:

•  Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.

•  Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399-434.

•  Li W et al. 2008 . Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a
mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3(1):e1487.

The candidate should have strong conceptual and experimental background in biochemistry and molecular biology. Expertise in the mechanistic dissection of signaling and in cancer biology and signaling is also desirable.
Experience with drug screening, enzyme kinetics, recombinant protein expression and purification, and mammalian cell culture are a plus. He/she must be proactive, hard working and productive, and must have excellent communication skills and desire to work in a fast-paced, multi-disciplinary collaborative team. The most competitive candidates will have at least one first-author publication (or article in press).

Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to:

Claudio Joazeiro
c/o Miriam Berba (Email:
The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd
La Jolla, CA  92037 USA

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