Molecular
Biology
of
Ubiquitin
Ligases:
Postdoctoral
Research
Position
A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).
Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease. Current projects include: 1) elucidating the role of MULAN, a mitochondria-associated E3, in the stress signaling response to ROS; 2) uncovering the function of LISTERIN, a novel ribosome-associated E3, in the quality control of aberrant nascent polypeptides; and 3) understanding how LISTERIN mutation causes ALS-like neurodegeneration in mice.
The position available is to elucidate mechanisms and critical biological functions of the above E3s. There are opportunities for studies on diverse lines, depending on the background and interests of the applicant: biochemistry, cell biology, molecular genetics with yeast and mammalian cells, analysis of animal models (flies and mice), genomic approaches (deep sequencing, siRNA collections), and others.
Selected references:
• Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.
• Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem . 78:399-434.
• Li W et al. 2008 . Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a
mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3(1):e1487.
The candidate should have strong conceptual and experimental background in biochemistry and molecular biology, as well as on the study of molecular mechanisms. Importantly, the candidate should be independent, hard working, proactive and productive, and should enjoy working in a team effort to make projects succeed. The most competitive candidates will have at least one first-author publication (or article in press).
Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro
c/o Miriam Berba (Email: mirberba@scripps.edu)
The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd
La Jolla, CA 92037 USA
Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease. Current projects include: 1) elucidating the role of MULAN, a mitochondria-associated E3, in the stress signaling response to ROS; 2) uncovering the function of LISTERIN, a novel ribosome-associated E3, in the quality control of aberrant nascent polypeptides; and 3) understanding how LISTERIN mutation causes ALS-like neurodegeneration in mice.
The position available is to elucidate mechanisms and critical biological functions of the above E3s. There are opportunities for studies on diverse lines, depending on the background and interests of the applicant: biochemistry, cell biology, molecular genetics with yeast and mammalian cells, analysis of animal models (flies and mice), genomic approaches (deep sequencing, siRNA collections), and others.
Selected references:
• Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.
• Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem . 78:399-434.
• Li W et al. 2008 . Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a
mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3(1):e1487.
The candidate should have strong conceptual and experimental background in biochemistry and molecular biology, as well as on the study of molecular mechanisms. Importantly, the candidate should be independent, hard working, proactive and productive, and should enjoy working in a team effort to make projects succeed. The most competitive candidates will have at least one first-author publication (or article in press).
Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro
c/o Miriam Berba (Email: mirberba@scripps.edu)
The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd
La Jolla, CA 92037 USA
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