Growth Hormone and Development

During development, genes are often transcribed in a temporally and spatially regulated manner. The murine growth hormone gene is differentially expressed in the developing pituitary gland. Lunyak et al. now examine the region surrounding the growth hormone gene and show that a repeated DNA sequence (short interspersed nuclear element B2) in the growth hormone locus functions as an insulator to produce a boundary for chromatin domains and limit the action of regulatory factors such as enhancers and silencers.

Source:

Developmentally Regulated Activation of a SINE B2 Repeat as a Domain Boundary in Organogenesis. Lunyak et al. Science 13 July 2007: Vol. 317. no. 5835, pp. 248 - 251.