In the nucleus, DNA is packaged into chromatin through association with histone proteins and this packaging needs to be modulated to enable genes to be expressed. Our understanding of how genes are transcribed in the context of chromatin is expanding, in part thanks to improvements in techniques that probe protein-DNA interactions. It is now known that, in eukaryotes, transcription by RNA polymerase II involves many protein complexes that modulate the chromatin structure.
This poster illustrates key relationships between transcription and chromatin, from recruitment of co-activators through to transcriptional elongation. Using illustrative examples, it shows how different stages of the transcription cycle can be rate limiting and shows some of the post-translational modifications that influence chromatin structure and transcriptional dynamics.
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