tag:blogger.com,1999:blog-272885542012-01-24T06:17:45.640-08:00Molecular Biology and BioinformaticsAdminnoreply@blogger.comBlogger961100tag:blogger.com,1999:blog-27288554.post-430052079951378852012-01-24T06:17:00.000-08:002012-01-24T06:17:45.648-08:00

PostDoc in insect RNA interference The Tomoyasu lab in the Zoology Department at Miami University seeks to hire a Postdoctoral Researcher to study the molecular basis of systemic RNA interference in beetles. Beetles have been shown to exhibit a robust systemic RNAi response, however, its molecular basis remains to be determined. The researcher will study the dsRNA uptake mechanism in the

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-55927380924423809352012-01-10T06:58:00.000-08:002012-01-10T06:59:23.403-08:00

The handheld Dino-Lite AM4113T-GFBW is a critical benefit to geneticists and bio-engineering researchers. Roanoke, Virginia (PRWEB) Microscope.com, in partnership with BigC.com, is pleased to introduce the Dino-Lite AM4113T-GFBW to the world of microscopy. With blue LEDs for excitation and a 510nm emission filter, this new microscope can observe green fluorescence protein (GFP)

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-25153955555565920932012-01-03T08:07:00.000-08:002012-01-03T08:07:04.849-08:00

Xuping Sun and co-workers, Chinese Academy of Sciences and King Abdulaziz University, Jeddah, Saudi Arabia, report a new application of zeolitic imidazolate framework-8 nanoparticles (ZIFNPs) as an effective sensing platform for the detection of fluorescence-enhanced nucleic acids. The DNA detection is accomplished in two steps: 1) the ZIFNP adsorbs and quenches the dye-labeled

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-431851914754214352011-09-16T11:47:00.000-07:002011-09-16T11:47:17.123-07:00

Select Biosciences is pleased to announce our Structural and Computational Chemistry Conference to be held 13th and 14th March 2012 in Munich, Germany, as part of the Discovery Chemistry Congress. CALL FOR PAPERS We are currently accepting oral abstract submissions for the conference. Please click here to submit an abstract if you would like to be considered to make a

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-69190491603850693922011-08-04T05:03:00.000-07:002011-08-04T05:03:29.614-07:00

Molecular
 Biology
 of 
Ubiquitin
 Ligases:
 Postdoctoral
Research
Position

  A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California). Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease. Current projects include: 1) elucidating the role of MULAN,

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-38109818738767015062011-08-04T04:34:00.000-07:002011-08-04T04:41:25.695-07:00

Development 
of 
Anti-­Cancer
 Drugs 
Targeting
 Ubiquitin  Ligases:
          Postdoctoral 
Research
 Position

                                                                          
 A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California). Research in the laboratory addresses mechanisms

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-90820423241133649802011-07-21T14:03:00.000-07:002011-07-21T14:07:23.490-07:00

Applications are now open for the second in a series of schools aimed at training students in Cognitiveand Neural Science research applied to learning and education. Applicants should be doctoral andpost-doctoral researchers interested in Cognitive Psychology, Cognitive Neuroscience, Mathematics,Education, Medicine and other disciplines related to cognition, brain, learning and education.

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-5388939012957005372011-07-21T13:45:00.000-07:002011-07-21T13:45:01.364-07:00

Chemical Evolution Generates Bacterial Strain With Artificial Nucleotide in its Genome Evolution is based on heredity, changes to the genetic material (mutation), and the natural selection of those organisms that are best suited to the given environmental conditions. An international team led by Rupert Mutzel at the Freie Universität of Berlin has now successfully emulated one particular

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-6012192546732379002011-07-01T06:13:00.000-07:002011-07-01T06:13:25.916-07:00

The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites. Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors. We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-91842812887664525832011-06-22T08:50:00.000-07:002011-06-22T08:50:05.106-07:00

Ion Channel Targets27 - 28 September 2011South San Francisco, CA, USA Select Biosciences is pleased to announce our 7th Annual Ion Channel Targets Conference, to be held on 27th and 28th September 2011 in South San Francisco, CA, USA. Call for Posters! We are currently accepting poster abstract submissions for the conference. Please click here to submit an abstract now and be a part of this event

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-47267693675403883352011-05-18T05:05:00.000-07:002011-05-18T05:05:08.600-07:00

Microorganisms around the globe have adapted to colonise environments over a broad range of temperature, from sub-zero to higher than 100°C, although no individual species can exist over a range greater than about 45°C. No particular species cannot exist outside of its temperature limits. This property is being tested by the current trends in climate change. For instance, sea-ice plankton have

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-53571763603713632372011-03-26T13:47:00.000-07:002011-03-26T13:47:18.238-07:00

The Interdisciplinary Stem Cell Institnute at the University of Miami is seeking a qualified individual to fill a Post Doctoral position in the laboratories of Dr. Claudia Rodrigues and Dr. Joshua Hare. The individual will undertake research related to understanding the molecular mechanisms involved in cardiac stem cell survival, self-renewal and differentiation.The applicant will be responsible

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-54689520304165166992011-03-08T01:39:00.000-08:002011-03-08T01:39:17.971-08:00

If you have not already registered for the upcoming 25th International Conference on Yeast Genetics and Molecular Biology, being held July 11th – 16th 2011 in Olsztyn-Kortowo, Poland, we would like to remind and encourage you to do so at this time. It’s a major event for investigators studying eukaryotic biology in yeast and will be held in the scenic Great Masurian Lakes region of northern

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-18430383481649161732011-02-25T02:59:00.000-08:002011-02-25T03:00:56.389-08:00

The Young Researchers in Life Sciences (YRLS) Federation has the pleasure to invite you to join the international ?Young Researchers in Life Sciences? meeting 2011. The meeting will take place in the Pasteur Institute (Paris) from the 9th to the 11th of May 2011. Young researchers (Master and PhD students as well as Postdocs) will have the possibility to present their work in the form of oral or

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-77414896829369277882011-01-31T07:44:00.000-08:002011-01-31T07:52:11.938-08:00

In the nucleus, DNA is packaged into chromatin through association with histone proteins and this packaging needs to be modulated to enable genes to be expressed. Our understanding of how genes are transcribed in the context of chromatin is expanding, in part thanks to improvements in techniques that probe protein-DNA interactions. It is now known that, in eukaryotes, transcription by RNA

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-17619064470031066512011-01-19T03:46:00.000-08:002011-01-19T03:46:28.457-08:00

This unique international conference provides a platform for all pharmaceutical scientists, internists and primary care physicians to discuss and learn about all the important international breakthrough developments on drug discovery and on new therapeutics. A conference organized by Eureka Science with support of the Higher Colleges of Technology, UAE, it focuses on the interdisciplinary fields

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-34692326777771510242011-01-08T06:41:00.000-08:002011-01-08T06:43:11.761-08:00

Recent years have witnessed rapid progress in elucidating the role of epigenetic modifications in nuclear organization and chromosome packaging, profoundly impacting our understanding of development, disease and natural variation. An increasingly diverse picture is emerging of the range of epigenetic mechanisms involved in regulating these processes, from DNA methylation and histone modification

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-37784355196576508512011-01-05T12:00:00.000-08:002011-01-05T12:00:11.441-08:00

Efforts to develop a simple blood test that can detect the presence and spread of cancer are poised to take a big step forward in 2011 now that Johnson & Johnson Co. is combining its efforts in this area with Massachusetts General Hospital. The two organizations Monday announced a collaboration to create a new technology for capturing, counting and characterizing cancerous tumor cells found in

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-31683827201495718812011-01-04T13:14:00.000-08:002011-01-04T13:14:10.101-08:00

Select Biosciences is pleased to announce our 7th Annual Ion Channel Targets Conference, to be held on 27th and 28th September 2011 in South San Francisco, CA, USA. CALL FOR PAPERS We are currently accepting oral abstract submissions for the conference. Please click here to submit an abstract if you would like to be considered to make a presentation at this event.Deadline 30th March 2011 Agenda

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-5250317732114121812010-12-25T03:35:00.000-08:002010-12-25T03:35:49.923-08:00

The main aim of this conference series is to present to a broad community the cutting edge developments in chromatin and epigenetics as they occur. Previous conferences of the series displayed one of the most exciting and steadily growing fields of research and provided an excellent platform to bring together top researchers working with different model organisms and methodological approaches

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-10376649045598729032010-12-22T12:14:00.000-08:002010-12-22T12:14:03.554-08:00

A postdoctoral position is available at the University of Miami Miller of Medicine to investigate the molecular mechanism of vesicle fusion by direct force measurements (see Abdulreda et. al., (2008) Biophys J.94:648-55). Our laboratory addresses emerging questions at the interface between physics and biology with a focus cellular processes such as adhesion and vesicle trafficking. Our research

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-13566374947202671822010-12-22T12:07:00.000-08:002010-12-22T12:07:25.287-08:00

Scientists from Imperial College London are developing technology that could ultimately sequence a person’s genome in mere minutes, at a fraction of the cost of current commercial techniques. The researchers have patented an early prototype technology that they believe could lead to an ultrafast commercial DNA sequencing tool within ten years. Their work is described in a study published this

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-76021013293219879402010-11-26T09:59:00.000-08:002010-11-26T09:59:34.033-08:00

Embryonic Stem Cells as a Model System for Embryonic Development’ is an evolving program based around an intense educational course with both practical training and lectures from key experts in the field. The 2011 version of the course will be held in Cuernavaca, Mexico, with outreach activities and symposium taking place in Mexico City (27th February to 17th March). The program aims to gather

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-6491576606882389742010-09-18T12:20:00.000-07:002010-09-18T12:20:42.964-07:00

Cell invasion and metastasis are the basis for most cancer-related deaths, and remain a central enigma and a crucial agenda for cancer research. It is increasingly evident that tumours developing in different organs use related but not identical strategies, likely reflective of the distinctive microenvironment they face during their ontogeny. Moreover, multiple cell types constituting the

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-6048972344236746102010-09-03T14:19:00.000-07:002010-09-03T14:19:11.802-07:00

A postdoctoral position is available immediately to study autonomic and/or behavioral thermoregulation in rats and mice with emphases on systemic inflammation, lipid mediators, TRP channels, and/or neural pathways.Background in integrative physiology, neuroanatomy, and molecular biology is desired, but dedication to work and enthusiastic interest in our research program are more important than

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-2531824365556021922010-09-03T13:03:00.000-07:002010-09-03T13:03:48.365-07:00

Institut Gustave Roussy Invites Applications for a Postdoc in Molecular Biology in Cancer at the Pediatric group of the CNRS Research Unit UMR 8203: "New therapeutic targets for nervous system tumors". A postdoc position is now open for highly motivated scientists with background in genetics, molecular biology, cell biology, and cancer. The projects are focused on studying molecular mechanisms of

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-17467138043008990942010-08-25T08:38:00.000-07:002010-08-25T08:38:49.824-07:00

Recent years have witnessed rapid progress in elucidating the role of epigenetic modifications in nuclear organization and chromosome packaging, profoundly impacting our understanding of development, disease and natural variation. An increasingly diverse picture is emerging of the range of epigenetic mechanisms involved in regulating these processes, from DNA methylation and histone modification

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-83700247662087241192010-08-21T15:44:00.000-07:002010-08-21T15:44:08.174-07:00

The availability of whole-genome association studies and emerging 'next-generation' sequencing technologies are redefining the genetic architecture of common diseases, revealing new susceptibility genes and offering new clues about mechanisms for a wide range of health disorders. The strategic focus of common disease genetics is progressing from the identification of susceptibility genes —

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-46601758625887580652010-06-18T14:05:00.000-07:002010-06-18T14:05:33.123-07:00

The Yeast Genetics and Molecular Biology Meeting registration deadline is Thursday, June 24. This is the one meeting you don't want to miss this year! In addition to all the excellent submitted abstracts that will be presented, the highlights include a symposium featuring Paul Nurse and Lee Hartwell (who shared the Nobel Prize in 2001) and Marc Garneau (Canadian Astronaut and Member of

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-13810199469850123092010-06-18T12:33:00.000-07:002010-06-18T13:53:12.531-07:00

The availability of whole-genome association studies and emerging 'next-generation' sequencing technologies are redefining the genetic architecture of common diseases, revealing new susceptibility genes and offering new clues about mechanisms for a wide range of health disorders. The strategic focus of common disease genetics is progressing from the identification of susceptibility genes — with

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-76094875157662941412010-05-19T11:36:00.000-07:002010-05-19T11:36:53.350-07:00

Ovarian cancer is the fifth leading cause of female cancer deaths in the UK and the seventh most common cancer in women in the USA, with more than 25,000 new diagnoses each year. It principally attacks women over the age of 50 and has a high mortality rate due to two key aspects which inhibit successful treatment. First of all, it is difficult to detect early. Only about 30% of ovarian cancers

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-9887022205984546932010-05-18T07:55:00.000-07:002010-05-18T07:55:47.140-07:00

August 30th to September 3rd, 2010 - Búzios, Rio de Janeiro - BrazilThe IWGD'10 is the third edition of the successful International Workshop on Genomic Databases one of the main workshops to be organized in Brazil focusing on genomic databases. It is organized by the BiowebDB consortium and it is intended to bring together researchers working on issues related to designing, managing,

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-81261997079256466372010-04-23T08:13:00.000-07:002010-04-23T08:44:46.888-07:00

Wiley/Wiley-VCH and ChemPubSoc Europe announce Symposium Frontiers of Chemistry: From Molecules to Systems, a one-day event in Paris in celebration of 10 years of the journals ChemBioChem and ChemPhysChem on May 21. Featuring no less than four Nobel laureates, it will be held in Paris, and simultaneously webcasted in a virtual event environment. The virtual event is free to attend, but you

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-27576562070448769692010-04-20T11:11:00.000-07:002010-04-20T11:11:32.090-07:00

When we cut or scrape ourselves, scarring is a normal part of the repair process. Connective tissue cells, known as fibroblasts, are deposited in the skin to form gristly fibres which hold the wound closed. In time, the scar will heal up completely to become invisible, or to leave a slight blemish at worst. However, in a small number of people, the fibroblasts continue to

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-88047409712387075052010-04-08T06:31:00.001-07:002010-04-08T06:34:57.824-07:00

This blog is now located at http://news-biomol.blogspot.com/. You will be automatically redirected in 30 seconds, or you may click here. For feed subscribers, please update your feed subscriptions to http://news-biomol.blogspot.com/feeds/posts/default.

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-76283474600897274122010-03-10T15:46:00.001-08:002010-03-10T15:46:53.382-08:00

Two postdoctoral position immediately available in the Johns Hopkins Bloomberg School of Public Health. The first project entails the functional characterization of the aquaporin (water channel) gene family in the malaria vector Anopheles gambiae. The ideal applicant will have expertise in general molecular biology techniques such as cloning, rtPCR etc…, antibody production and RNA interference

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-11442962145073791142010-02-18T08:33:00.000-08:002010-02-18T08:33:53.944-08:00

Cancer in all its inglorious forms remains a killer but there are signs that the huge investment in cancer research, improvements in cancer care and, possibly, lifestyle changes, are having an effect. In the USA, the National Cancer Institute announced that the rates of new diagnoses fell about 1% per annum from 1999-2006 while death rates from all cancers dropped about 1.6% per annum from 2001-

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-46376909572237218342009-05-27T09:46:00.000-07:002009-05-27T09:48:31.045-07:00

The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly. The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence,

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-37350938228716402882009-02-23T05:45:00.000-08:002009-02-23T05:48:28.438-08:00

Classical and emerging infectious diseases, viral pandemics, and drug-resistant pathogens remain challenges to human health. However, contemporary advances in genetics and genomic technologies provide new approaches to understanding and combating these diseases. ASHG and HUGO are partnering with NPG to organize an international conference to discuss how the genomes, unique biologies, and

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-45873300362991549292008-11-25T14:05:00.000-08:002008-11-25T14:11:48.160-08:00

The human genome has hidden levels of regulatory complexity and variability that have begun to reveal themselves since the initial sequence became available in 2001. Today, with increasingly powerful sequencing and analysis technologies, we are not only beginning to appreciate the scale of variation in individual human genome sequences, but also gaining a greater understanding of how genome

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-54668356700591809352008-11-24T03:44:00.000-08:002008-11-24T03:48:17.751-08:00

In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths and noted differences among individual specimens. Subsequently, DNA sequences have been published for a number of extinct species. However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused on short mitochondrial sequences, never yielding more than a fraction of a per

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-38667718474071895062008-11-18T14:56:00.000-08:002008-11-18T15:04:26.598-08:00

What genes and regulatory sequences contribute to the organization and functioning of neural circuits and molecular pathways in the brain that support social behavior? How does social experience interact with information in the genome to modulate brain activity? Here, we address these questions by highlighting progress that has been made in identifying and understanding two key "vectors of

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-41358996604782064552008-09-01T03:55:00.000-07:002008-09-01T03:56:44.048-07:00

In the fission yeast Schizosaccharomyces pombe, the nucleus is tethered to the cytoskeleton by KASH domain-containing proteins in the outer nuclear membrane and SUN domain-containing proteins in the inner nuclear membrane. By exerting force on these SUN-KASH complexes, the cytoskeleton controls the position of the nucleus within the cell. Centromeric DNA inside the nucleus has been observed to

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-69116907917775623762008-08-09T15:40:00.000-07:002008-08-09T15:45:17.229-07:00

A Postdoctoral position is available for research in the areas of STEM CELLS AND NEURODEVELOPMENT. The laboratory, headed by Dr. Alysson R. Muotri, make use of human ES and iPS cells, in combination with genetic, molecular, biochemical and computationaltools, to study early stages of brain development and the formation of neuronal networks.Research currently focuses on two interconnected projects

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-50674630875436652052008-08-07T13:05:00.000-07:002008-08-07T13:09:55.153-07:00

Mitochondria are responsible for maintaining the energy balance of the cell and are also responsible for triggering apoptosis (programmed cell death) in response to oxidative stress. This one-day mini-symposium aims to highlight recent advances in our understanding of how these organelles function in the nervous system, and how mitochondrial dysfunction contributes to neurological

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-69139480560518242212008-08-01T15:02:00.000-07:002008-08-01T15:04:51.872-07:00

The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell-types affected by that patient’s disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell-replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-81992161589769595652008-03-19T05:18:00.000-07:002008-03-19T05:22:55.022-07:00

Prion proteins are linked to several diseases, including bovine spongiform encephalopathy in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease in humans. Infectious prion-like proteins that also form amyloid fibrils are found in yeast and other fungi. Based on solid-state nuclear magnetic resonance data, Wasmer et al. provide a structural model of amyloid fibrils from the prion-forming

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-63319766382775338402008-03-11T07:19:00.000-07:002008-03-11T07:40:55.337-07:00

Although autism is highly heritable, sorting out the genes associated with this complex disease has been difficult. Weiss et al. searched for structural mutations (duplications or deletions below the level of microscopic detection) in the genomic DNA of 751 families who are part of the Autism Genetic Resource Exchange. They found a significant association of autism with a nearly 600-kb region

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-43626576963976618612008-02-18T04:19:00.000-08:002008-02-18T04:24:26.271-08:00

Genomics revolutionized genetic research. Now, complete annotated genome sequences are available for the human, our closest relative, the chimpanzee, and for many other model organisms. Multiple genomes have been compared and scrutinized for past and ongoing processes of variation, adaptation and speciation. Traces of the foregoing RNA world show it to be far more influential than previously

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-87130943407589867382008-02-08T05:32:00.000-08:002008-02-08T07:06:24.982-08:00

Bonneau et al. describe progress in an effort to link systems-level analysis to events at the molecular and organismal levels. Using experiments and computation, they have pooled transcriptome, protein-protein interaction, structural, and evolution-related data to generate a dynamic model of the halophilic organism Halobacterium salinarum. This model was trained on data sets that included more

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-92225440361938228612008-02-02T05:10:00.000-08:002008-02-02T05:15:18.519-08:00

Many examples have been reported of assembly of atoms and small molecules into patterns on surfaces by pick up, transfer, and release with a scanning probe microscope tip under vacuum conditions. Kufer et al. assembled larger single molecules into patterns on surfaces in aqueous solution with an atomic force microscope (AFM) tip by taking advantage of differential forces acting on double-stranded

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-22247240179657431942008-01-13T02:44:00.000-08:002008-01-13T02:46:29.203-08:00

The Computational Genomics Laboratory (www.evocell.org) is looking fora post-doctoral fellow to work on the origins and evolution ofintracellular compartmentalization and protein trafficking pathways,and a second post-doctoral fellow to work, in collaboration with theCell Cycle Regulation Lab (http://sites.igc.gulbenkian.pt/ccr/), inthe evolution of centrioles and their regulatory pathways.

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-55493757665013991752007-12-22T09:05:00.000-08:002007-12-22T09:13:56.992-08:00

Chronic obstructive pulmonary disease (COPD) is one of the most common adult respiratory diseases worldwide and the fourth leading cause of death. The American Lung Association estimates that about 15 million US citizens are affected. In the UK, the 30,000 deaths annually mean that more die of COPD than from breast, colon or prostate cancer. Despite the high prevalence, COPD is preventable and

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-70866584108006155742007-09-05T05:39:00.000-07:002007-09-05T06:05:27.567-07:00

Presented here is a genome sequence of an individual human. It was produced from ∼32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled into 4,528 scaffolds, comprising 2,810 million bases (Mb) of contiguous sequence with approximately 7.5-fold coverage for any given region. We developed a modified version of the Celera assembler to facilitate the identification

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-9357378089332613912007-08-14T16:06:00.000-07:002007-08-14T16:16:04.466-07:00

Characterization of interspecies differences in gene regulation is crucial for understanding the molecular basis of both phenotypic diversity and evolution. By means of chromatin immunoprecipitation and DNA microarray analysis, the divergence in the binding sites of the pseudohyphal regulators Ste12 and Tec1 was determined in the yeasts Saccharomyces cerevisiae, S. mikatae, and S. bayanus under

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-18621233939323007702007-08-10T07:22:00.000-07:002007-08-10T07:28:29.066-07:00

Adeno-associated viruses (AAV) are promising gene therapy vectors that have little or no acute toxicity. We show that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase. AAV proviruses were isolated from four tumors and were all located within a 6-kilobase region of chromosome 12

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-47288794583593568712007-07-16T07:18:00.000-07:002007-07-16T07:25:59.981-07:00

During development, genes are often transcribed in a temporally and spatially regulated manner. The murine growth hormone gene is differentially expressed in the developing pituitary gland. Lunyak et al. now examine the region surrounding the growth hormone gene and show that a repeated DNA sequence (short interspersed nuclear element B2) in the growth hormone locus functions as an insulator to

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-71520393921395104902007-07-01T07:07:00.000-07:002007-07-01T07:11:23.083-07:00

As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol-mediated transformation. Cells selected for

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-20018030348481621182007-06-20T05:55:00.000-07:002007-06-20T06:00:03.261-07:00

The venom itself is a cocktail of low- and high-molecular-weight components, the toxins constituting a very small proportion of these, often only one compound. They can be classified according to their mode of action and include neurotoxins (acting on the nervous system), cardiotoxins (heart), haemorrhagins (blood vessels), haemotoxins (blood), nephrotoxins (kidney), necrotoxins (tissue) and

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-16813568750298648952007-06-15T07:09:00.000-07:002007-06-15T07:12:18.359-07:00

Random cell-to-cell variations in gene expression within an isogenic population can lead to transitions between alternative states of gene expression. Little is known about how these variations (noise) in natural systems affects such transitions. In Bacillus subtilis, noise in ComK, the protein that regulates competence for DNA uptake, is thought to cause cells to transition to the competent

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-47202675326369239032007-05-06T06:12:00.000-07:002007-05-06T06:16:32.441-07:00

Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (n> 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-50937582368587440392007-04-15T16:56:00.000-07:002007-04-15T17:17:00.624-07:00

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-47265612953635689082007-04-06T05:08:00.000-07:002007-04-06T05:12:13.613-07:00

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-28101304265173195232007-03-31T16:21:00.000-07:002007-03-31T16:23:48.517-07:00

The liver is one tissue in mammals that can regenerate. Passino et al. now find that hepatocyte proliferation is controlled by the neurotrophin receptor p75NTR, known primarily for its role in neurons in regulation of survival, apoptosis, and neuronal regeneration. Mice lacking p75NTR showed impaired hepatocyte proliferation. p75NTR appeared to act on hepatic stellate cells (HSCs), which

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-31723658170574873952007-03-10T04:13:00.000-08:002007-03-10T04:20:44.731-08:00

The range of mutations that can drive cancer growth could be much wider than thought. An international research effort called the Cancer Genome Project has identified around 120 new genes that contain mutations promoting the disease."This is a lot more cancer genes than we expected to find," says Michael Stratton of the Wellcome Trust's Sanger Institute in Cambridge, UK, one of the leaders of the

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-17525285272868547252007-02-20T02:58:00.000-08:002007-02-20T03:01:48.427-08:00

As animal cells migrate across a surface, they send out processes known as filopodia that explore the substratum. Galbraith et al.  now find that the intracellular actin network directs very local protrusions that contain clusters of cell surface-adhesion molecules at their tips that are primed to interact with molecules of the extracellular matrix. These "sticky fingers" at the leading edge of

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1171541853539980862007-02-15T04:10:00.000-08:002007-02-15T04:17:33.560-08:00

Medical researchers have found a chink in the constantly shape-shifting armour of the HIV virus. The discovery could be a significant step forward in the ongoing quest for a vaccine.The AIDS virus evades the immune system because most of the proteins that cover the surface of the virus constantly change their structure. But researchers have now identified a site that doesn't change, and shown how

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1169118064174031082007-01-18T02:57:00.000-08:002007-01-18T03:01:04.186-08:00

Trichomonas vaginalis is a common but often neglected sexually transmitted pathogen that colonizes the urogenital tract in men and women. Carlton et al. describes its genome, which at 160 megabases is significantly larger than any other parasitic protest known so far, and which provides insight into the parabasilids, which lack mitochodria and peroxisomes and instead bear organelles called

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1166786103641492462006-12-22T02:56:00.000-08:002006-12-22T03:15:03.660-08:00

Two groups of beneficial bacteria are dominant in the human gut, the Bacteroidetes and the Firmicutes. Here we show that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Our findings indicate that obesity has a microbial component, which might have potential

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1164489664474065172006-11-25T13:17:00.000-08:002006-11-25T13:21:04.490-08:00

The clock genes that control circadian rhythms in mammals also contribute to other aspects of physiology, behavior, and health. One such clock gene, Bmal1, encodes a transcription factor whose inactivation in mice causes disturbances in circadian rhythms and alterations in activity level, body weight, and other physiological functions. By reexpressing the Bmal1 gene in selective tissues in Bmal1-

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1162503161742903492006-11-02T13:29:00.000-08:002006-11-02T13:32:41.760-08:00

Predicting time of food availability is key for survival in most animals. Under restricted feeding conditions, this prediction is manifested in anticipatory bouts of locomotor activity and body temperature. This process seems to be driven by a food-entrainable oscillator independent of the main, light-entrainable clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Although the

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1160576896239670692006-10-11T07:25:00.001-07:002006-10-11T07:28:16.240-07:00

The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable for depression. We investigated the underlying neural mechanisms of these epigenetic processes in individuals with no history of psychopathology by using multimodal magnetic resonance-based

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1159878445148306822006-10-03T05:18:00.000-07:002006-10-03T05:33:53.580-07:00

This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information. Our genome operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. These instructions are conveyed by messenger RNA (mRNA). In 1998, the American scientists Andrew Fire and Craig

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1159804712313019662006-10-02T08:43:00.000-07:002006-10-02T08:58:32.326-07:00

New genomic tool makes connections between drugs and human disease.While the ultimate goal of biomedicine is to connect each human disease with drugs that can effectively treat or cure it, the paths toward this goal are often circuitous. The earliest steps, in particular, can be hindered by a lack of basic knowledge about how drugs and diseases work — for example, the biology that underlies a

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1159274752620644232006-09-26T05:43:00.000-07:002006-09-26T05:45:52.636-07:00

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-ß (Aß)–containing brain extracts from humans with Alzheimer's disease or ß-amyloid precursor protein (APP) transgenic mice induced cerebral ß-amyloidosis and associated pathology in APP transgenic mice in a

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1157374051127364852006-09-04T05:43:00.000-07:002006-09-04T05:47:31.146-07:00

Using adoptive transfer of lymphocytes given after host immunodepletion it is possible to mediate objective cancer regression in patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Using a retrovirus encoding a T cell receptor, we report here the ability to specifically confer tumor recognition by autologous

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1156949049582249572006-08-30T07:37:00.000-07:002006-08-30T07:44:09.610-07:00

Mutation and aberrant expression of apoptotic proteins are hallmarks of cancer. These changes prevent proapoptotic signals from being transmitted to executioner caspases, thereby averting apoptotic death and allowing cellular proliferation. Caspase-3 is the key executioner caspase, and it exists as an inactive zymogen that is activated by upstream signals. Notably, concentrations of procaspase-3

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1156634641527802182006-08-26T16:15:00.000-07:002006-08-26T16:24:02.380-07:00

Led by Dr. Amy Lee, professor of biochemistry and molecular biology in the Keck School of Medicine of the University of Southern California, the researchers have isolated a gene that some breast tumors produce at high levels, which protects the tumor from a common chemotherapy regimen. The findings are published as a "Priority Report" in the August 15 issue of Cancer Research. "The importance of

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1155065583450016262006-08-08T12:27:00.000-07:002006-08-08T12:33:03.483-07:00

Using a new genomic strategy that has the power to survey the entire human genome and identify genes with common variants that contribute to complex diseases, researchers at Johns Hopkins, together with scientists from Munich, Germany, and the Framingham Heart Study, U.S.A., have identified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1154274506978290862006-07-30T08:42:00.000-07:002006-07-30T08:48:27.003-07:00

Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.The protein, called DNA polymerase lambda, is one of a group of proteins known as DNA polymerases that are vital for accurately making and repairing DNA.But while other DNA-repair proteins insure their accuracy with the help of so-called

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1153686296419865592006-07-23T13:22:00.000-07:002006-07-23T13:24:56.433-07:00

A fingerprint of gene activity could reveal the true 'youthfulness' of our kidneys, hearts and muscle, regardless of our biological age. The technique might one day be used to find healthy organs for transplants or to warn us of impending disease.It's hard to tell, particularly on a cellular level, whether a young and healthy body conceals a withering heart — or conversely, whether an old man has

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1153596657860888942006-07-22T12:26:00.000-07:002006-07-22T12:30:57.876-07:00

We have the modern human genome. Now researchers are set to sequence the DNA of our extinct cousins: Neanderthal man.The Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, in collaboration with 454 Life Sciences Corporation, in Branford, Connecticut, today announce a plan to have a first draft of the Homo neanderthalensis genome within two years. Comparing the result to

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1152714073626717002006-07-12T07:18:00.000-07:002006-07-12T07:21:13.643-07:00

A software package called ARP/wARP is helping to expose the hidden world of biological molecules.In the early days of X-ray crystallography obtaining a three-dimensional model of a protein required wire models, screws, bolts and years of tedious calculations by hand. Today macromolecular models are built by computers – thanks to sophisticated software and in particular a package called ARP/wARP.

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1152713778746974182006-07-12T07:11:00.000-07:002006-07-16T11:15:56.063-07:00

Researchers at The Scripps Research Institute and The Skaggs Institute for Chemical Biology have developed a unique assembly strategy to produce an anticancer targeting antibody, an approach that combines the merits of small molecule drug design with immunotherapy.Among the potential therapeutic advantages of this approach is a dramatically increased circulatory half-life of the compound, which

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1151191803794380782006-06-24T16:25:00.000-07:002006-06-24T16:30:03.810-07:00

If heart disease and diabetes aren’t bad enough, now comes another reason to watch your weight. According to a study just released, packing on too many pounds can increase the risk of developing Alzheimer’s disease.A team led by researchers at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia and Edith Cowan University in Joondalup, Western Australia has shown

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1150639560628587872006-06-18T06:51:00.000-07:002006-06-18T07:06:00.646-07:00

The use of computers to advance human disease research – known as bioinformatics -- has received a major boost from researchers at the La Jolla Institute for Allergy & Immunology (LIAI), who have used it to successfully predict immune response to one of the most complex viruses known to man – the vaccinia virus, which is used in the smallpox vaccine. Immune responses, which are essentially how

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1150317600630519082006-06-14T13:35:00.000-07:002006-06-14T13:40:00.650-07:00

Conversion factor for adult cells could sidestep cloning controversy. Biologists say they are close to finding a cellular elixir of youth: a cocktail of proteins that can convert adult cells into embryonic stem cells that are able to grow replacement tissues.Two studies published in Nature1,2 identify key proteins that endow embryonic stem cells with their coveted abilities to divide again and

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1149017008349210672006-05-30T12:12:00.000-07:002006-05-30T12:23:28.386-07:00

Using RNA interference to shut down harmful genes can have fatal flaw.The research shows that mice can die when injected with high doses of a form of RNA. The RNA molecules, which were folded into structures called short hairpin RNAs (shRNAs), were able to overwhelm a cell's normal RNA-processing mechanisms, with fatal consequences.Researchers say the work emphasizes the need to proceed carefully

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1148489896473176112006-05-24T09:45:00.000-07:002006-05-24T09:58:16.486-07:00

Biologists looking for an efficient way to halt the spread of avian flu have hit upon a promising twofer. By inserting an avian flu gene into a vaccine that protects against another bird malady, researchers have developed a vaccine that could combat both. If successful, the vaccine may offer an alternative to the mass slaughterings that have cost the world's poultry industry millions in lost

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1147809200692875362006-05-16T12:26:00.000-07:002006-05-16T12:53:20.706-07:00

A study of the nematode worm Caenorhabditis elegans suggests that chemicals in mothballs shut down the natural process by which cells commit suicide, allowing cancer cells to divide and conquer.The finding is serendipitous. When a neighboring lab became infested by mites, biochemist Ding Xue of the University of Colorado in Boulder tried to protect his C. elegans by putting mothballs in their

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1147295750474115972006-05-10T14:10:00.000-07:002006-05-10T14:15:50.486-07:00

Drawing on various databases, ENDEAVOUR gathers all the data about genes that are known to be connected with a disease or a biological process and integrates these data into a mathematical model. With the aid of this model, scientists study the similarities between the 'known genes' and genes whose biological function is not yet known. ENDEAVOUR then indicates whether these genes might possibly

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1147178780185337542006-05-09T05:13:00.000-07:002006-05-09T05:46:20.206-07:00

A number of studies have shown that restricting calories increases the lifespan of animals, but the biological basis for this has remained elusive. A new report hints that growth hormone, as well as insulin, are key factors in the life-extending effects of calorie restriction."The implication ... for pharmaceutical development would be that the signaling pathways of growth hormone and insulin may

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1147015367046730972006-05-07T08:12:00.000-07:002006-05-07T08:22:47.056-07:00

Close on the heels of the discovery that cancer has its own rejuvenating stem cells, a University of Michigan research team has found a way to distinguish these bad-actors from the normal stem cells that they so closely resemble, and to kill the cancer stem cells without harming the normal stem cells in the same tissue.The progression of some cancers, including leukemia, appears to be driven by

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1146509124356842802006-05-01T11:38:00.000-07:002006-05-01T11:45:24.370-07:00

Using a new genomic strategy that has the power to survey the entire human genome and identify genes with common variants that contribute to complex diseases, researchers at Johns Hopkins, together with scientists from Munich, Germany, and the Framingham Heart Study, U.S.A., have identified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1146424928599093442006-04-30T11:34:00.000-07:002006-04-30T12:22:08.620-07:00

Chronic fatigue syndrome appears to result from something in people's genetic makeup that reduces their ability to deal with physical and psychological stress, researchers reported Thursday.The research is being called some of the first credible scientific evidence that genetics, when combined with stress, can bring on chronic fatigue syndrome -- a condition so hard to diagnose and so poorly

Adminnoreply@blogger.com0tag:blogger.com,1999:blog-27288554.post-1146350644503046412006-04-29T15:37:00.000-07:002006-04-29T16:47:26.633-07:00

EMBOSS, the European Molecular Biology Open Software Suite, has received new funding from the Biotechnology and Biological Sciences Research Council (BBSRC) in the United Kingdom that ensures its survival as an open-source utility, at least for the next three years.The fate of the EMBOSS project had been in doubt for the past two years, following the closure last summer of the Rosalind Franklin

Adminnoreply@blogger.com0